iGReD G¨¦n¨¦tique, Reproduction et D¨¦veloppement

UMR 6293 CNRS / UMR 1103 Inserm / UCA
- Adresse :
- UFR de Pharmacie / UFR de M¨¦decine et des Professions param¨¦dicales
TSA 50400
28, Place Henri Dunant
63001 CLERMONT-PT招财进宝
- T¨¦l :
- 04-73-17-81-70
- Sur Internet :
- www.gred-clermont.fr/
Responsables
- Directeur de laboratoire
- Krzysztof JAGLA
- Directrice Adjointe
- Anne FOGLI
- Gestionnaire d'unit¨¦
- Franck TEILLET franck.teillet@uca.fr
- Gestionnaire d'unit¨¦
- Veronique TRONCY veronique.troncy@uca.fr
Composition ¨¦quipe ( effectif total : 164 )
- BOUVIER Damien -
- CHIAMBARETTA Frederic -
- COSTE Karen -
- FOGLI Anne -
- FUTIER Emmanuel -
- GALLOT Denis -
- GOUMY Carole -
- JABAUDON GANDET Matthieu -
- MARCEAU Geoffroy -
- QUINARD Regine -
- SAPIN DEFOUR Vincent -
- TAUVERON Igor -
- BARDOT Olivier -
- BARON Silvere -
- BEAUDOIN Claude -
- BLANCHON Loic -
- BRASSET Emilie -
- CAIRA Francoise -
- CALET Corinne -
- COTTERELL Sylviane -
- DE JOUSSINEAU Cyrille -
- DREVET Joel -
- GUITON Rachel -
- KOCER Ayhan -
- LAGEIX Sebastien -
- LE GOFF Samuel -
- LOBACCARO Jean Marc -
- MARTINEZ Anne Marie -
- MOREL Laurent -
- OSTEIL Pierre -
- POINTUD Jean Christophe -
- SAEZ Fabrice -
- SOLER Cedric -
- TATOUT Christophe -
- TROUSSON Amalia -
- TUTOIS Sylvie -
- VAILLANT Isabelle -
- VANROBAYS Emmanuel -
- VAURS BARRIERE Catherine -
- ROSZYK Laurence -
- AMIARD Simon -
- ARNAUD Philippe -
- CHARBONNEAU Michel -
- CHAZAUD Claire -
- COURT Franck -
- DA INES Olivier -
- DEGOUL Francoise -
- EYCHENNE Julia -
- GRANDIN Nathalie -
- GUILLOT Charlene -
- JAGLA Krzysztof -
- JENSEN Silke -
- JUNION Guillaume -
- MARTINEZ Antoine -
- MATHIEU Olivier -
- MIROUSE Vincent -
- MOLARO Antoine -
- PELISSIER Thierry -
- PROBST Aline -
- SERRA Heidi -
- VAL Pierre -
- VANDEL Laurence -
- VOLLE David -
- WALTZER Lucas -
- WHITE Charles -
- BELVILLE Corinne -
- DESSET Sophie -
- HOLOTA Helene -
- IMBERT ROUX Lauriane -
- JAGLA Teresa -
- MAUPETIT MEHOUAS Stephanie -
- MOUTY Lea -
- PELISSIER Marie Noelle -
- POUCHIN Pierre -
- RENAUD Yoan -
- VACHIAS Caroline -
- ALEGOT Herve -
- ALLEGRE Nicolas -
- BARNOLA Isabelle -
- BOUTOURLINSKY Katia -
- CLERICI Ornella -
- DAMON Christelle -
- DE HAZE Angelique -
- FRAISSE Marine -
- GARNIER Cecile -
- GERDY Vincent -
- GONTHIER GUERET Celine -
- MORDIER Joris -
- PERILLOUS Sophie -
- REY Celia -
- RICHARD Graziella -
- RONGIER Ga?tan -
- TEILLET Franck -
- VADOT Francoise -
- GARCIA GARCIA Diana -
- KAUR Raminder -
- KUMAR Rohit -
- MATA SUCRE Yennifer -
- MAURELIA GAETE Felipe Alonso -
- MONTIBUS Bertille -
- OLIVIER Margaux -
- PANG Won Ki -
- PRINCE Elodie -
- SANMUKH Swapnil Ganesh -
- TOMASEK Ines -
- VOISIN Allison -
- ANGLARET Nadege -
- BERTRAND Romane -
- BRAVARD Stephanie -
- BRUNEL Maryse -
- BUISINE Monique -
- CADENA Claire -
- DIOMANDE Corinne -
- GOMEZ Eric -
- GUEGUEN Nathalie -
- MARTINEZ Marie Jose -
- PRADEL Vanessa -
- SANCHEZ VILLAVICENCIO Phelipe -
- TRONCY Veronique -
- VERBEKE Jeremy -
- VERDIER Manon -
- BAABDATY Elissa -
- BADOIL Lena -
- BIOLET Eloise -
- BRUGIERE Line -
- CHALEIL Florian -
- CURCI Martina -
- DAJOUX Gabin -
- DE SOUSA Martina -
- DELPORTE Norberta -
- EL IDRISSI MOUBTASSIM Hafsa -
- FEIT Lea -
- GERDY Vincent -
- HARISMENDY Nathan -
- JUVEN Aurelien -
- KAHOUADJI Samy -
- KARAM Germaine -
- KUZNETSOVA Ekaterina -
- LASCOVITCH Leila -
- LENOIR Naell -
- LUGOBONI Margot -
- LUZZI Irene -
- MAGALES Chloee -
- MIGNY Chloe -
- MOCHET Etienne -
- OLABE Julie -
- PALTRINIERI Stefania -
- PARACCHINI Sara -
- PATIN Anaelle -
- PAULUS Violaine -
- PETIOT Valentine -
- PRIKSHIT Prikshit -
- PURAVET Antoine -
- PUTTINI PAIXAO Joao -
- ROBIN Justine -
- SIRETA Gilles -
- TESTE Camille -
- THEILLIERE Camille -
- WEST Elliot -
- HENRIOUX Fanny -
- KAHOUADJI Samy -
- OUEDRAOGO Zangbewende Guy -
- RAGOT Elia -
- SIMON Lauriane -
Equipes
- CODED : ChrOmatin & 3D nuclEar Dynamics , Christophe TATOUT , Aline PROBST
- Diversification of muscle and heart cells in normal and pathological conditions , Krzysztof JAGLA
- Dynamic Regulation of Body Axis Morphogenesis , Charlene GUILLOT
- ERO : Epigenetic Regulation & Ontogenesis , Lucas WALTZER
- Environment, Spermatogenesis, Pathophysiology and Inheritance , David VOLLE
- Epithelial growth and Morphogenesis , Vincent MIROUSE
- Evolutionary Epigenomics and Genetic Conflicts , Antoine MOLARO
- Genomic Imprinting and the epigenetic control of cell fate determination , Philippe ARNAUD
- Gin&Co : Genetic instabilities and control by the host genome , Emilie BRASSET , Chantal VAURY
- Molecular Pathophysiology of @drenal & Endocrine Tissues , Antoine MARTINEZ , Pierre VAL
- Molecular mechanisms of cell lineage differentiation in the early mouse embryon , Claire CHAZAUD
- NuReP : Nuclear Receptors and Prostate diseases , Silvere BARON , Jean Marc LOBACCARO
- Recombination and maintenance of genome integrity , Charles WHITE
- SiLENT : Silencing, Environment and Transposons , Olivier MATHIEU
- Transliational approach to epithelial injury and repair , Vincent SAPIN DEFOUR
Th¨¨mes de Recherche
Version Fran?aise English versionLe iGReD (Laboratoire de G¨¦n¨¦tique, Reproduction et D¨¦veloppement) cherche ¨¤ comprendre les m¨¦canismes mol¨¦culaires et cellulaires qui contr?lent la formation d'un organisme eucaryote ¨¤ partir d'un oeuf f¨¦cond¨¦. Les ¨¦quipes qui le composent, analysent les syst¨¨mes de surveillance et de r¨¦paration qui maintiennent l'int¨¦grit¨¦ des g¨¦nomes. Elles ¨¦tudient comment d'une cellule indiff¨¦renci¨¦e, divisions et diff¨¦renciations cellulaires conduisent ¨¤ la formation d'un individu harmonieusement d¨¦velopp¨¦.
Prolongeant ces aspects fondamentaux, des approches m¨¦dicales visent ¨¤ ¨¦lucider le programme g¨¦n¨¦tique d'une cellule saine, identifier les d¨¦r¨¦gulations de certaines pathologies, et trouver des th¨¦rapeutiques adapt¨¦es.
Cette unit¨¦ se d¨¦cline en trois th¨¨mes majeurs:
Dynamique du g¨¦nome et contr?le ¨¦pig¨¦n¨¦tique,
Reproduction et d¨¦veloppement normal et pathologique
Endocrinologie et signalisation,
Les approches utilis¨¦es allient biologie mol¨¦culaire et cellulaire, imagerie et cribles g¨¦n¨¦tiques. L'utilisation de plusieurs mod¨¨les eucaryotes (vert¨¦br¨¦s, insectes, plantes) permet d'exploiter les avantages particuliers de chacun.
Research in the GReD concerns the molecular and cellular mechanisms brought into play to ensure maintenance of genome integrity and gene expression, differentiation and development. Our research concerns three major themes:
Genome dynamics and epigenetic control
reproduction and development in health and disease
Endocrinology and signaling
The three research axes thus combine molecular and cellular biology approaches, imaging and genetic screens. The use of multiple biological models (vertebrates, insects, plants) permits us to exploit the particular advantages of each for research and experimentation. This work, and notably the study of human genetic diseases including cancer, has great potential for technology transfer to clinical applications - in line with our strategic scientific policy to strengthen the continuum between basic and clinical research.
The strengths of the Unit:
Complementarity of technical approaches and models.
Coordination and sharing of cutting-edge technical facilities.
High potential for the transfer of technology to clinical applications, in keeping with the marketing policy.
Significant training activities within universities in Clermont-Ferrand.
Publications ( HAL )
- CTCF-dependent insulation of Hoxb13 and the heterochronic control of tail length
D. Duboule , Hocine Rekaik , Lucille Lopez-Delisle , Jozsef Zakany , C¨¦lia Bochaton , Pierre Osteil , Alexandre Mayran , Fabrice Darbellay , B¨¦n¨¦dicte Mascrez - Efficacy of medical treatments for vernal keratoconjunctivitis: A systematic review and meta-analysis
In¨¨s Roumeau , Adrien Coutu , Valentin Navel , Bruno Pereira , Julien Baker , Fr¨¦d¨¦ric Chiambaretta , Dominique Bremond-Gignac , Fr¨¦d¨¦ric Dutheil - Will environmental impacts of social distancing due to the pandemic caused by SARS-CoV-2 decrease allergic disease?
Valentin Navel , Fr¨¦d¨¦ric Chiambaretta , Fr¨¦d¨¦ric Dutheil - Reply to "The bimodal SARS-CoV-2 outbreak in Italy as an effect of environmental and allergic causes
Valentin Navel , Fr¨¦d¨¦ric Chiambaretta , Fr¨¦d¨¦ric Dutheil - Reply to "Global lockdown, pollution, and respiratory allergic diseases: Are we in or are we out?
Valentin Navel , Fr¨¦d¨¦ric Chiambaretta , Fr¨¦d¨¦ric Dutheil - Coronavirus: good or bad news for ocular diseases?
Valentin Navel , Fr¨¦d¨¦ric Chiambaretta , Fr¨¦d¨¦ric Dutheil - COVID©\19, sweat, tears¡ and myopia?
Valentin Navel , Steven Beze , Fr¨¦d¨¦ric Dutheil - Myopia and Near Work: A Systematic Review and Meta-Analysis
Fr¨¦d¨¦ric Dutheil , Tharwa Oueslati , Louis Delamarre , Joris Castanon , Caroline Maurin , Fr¨¦d¨¦ric Chiambaretta , Julien Baker , Ukadike Ugbolue , Marek Zak , Ines Lakbar , Bruno Pereira , Valentin Navel - Myopie et travail professionnel de pr¨¨s ¨¤ l¡¯?ge adulte : revue syst¨¦matique et m¨¦ta-analyse
Fr¨¦d¨¦ric Dutheil , Joris Castanon , Caroline Maurin , Martial Mermillod , Fr¨¦d¨¦ric Chiambaretta , Ma?lys Clinchamps , Fran?ois-Xavier Lesage , Bruno Pereira , Valentin Navel - ?valuation de l¡¯efficacit¨¦ du champ visuel FDT (Frequency Doubling Technology) dans le d¨¦pistage du glaucome chronique en M¨¦decine du travail
Fr¨¦d¨¦ric Dutheil , C¨¦dric Benoist D¡¯azy , Bruno Pereira , Frederic Chiambaretta , Gil Boudet , Maelys Clinchamps , Valentin Navel
Production scientifique depuis 2021
- DIAGNOSTIC DE L'OXYDATION DU NOYAU SPERMATIQUE - 2022
- Utilisation du dosage sanguin de la chimiokine CX3CL1 chez la femme enceinte - 2023
- CARACTERISATION DE PEPTIDES ANTIGENIQUES / IMMUNOGENIQUES POUR LE DEVELOPPEMENT DE VACCINS CONTRACEPTIFS DANS LE BUT DE LIMITER LES PULLULATIONS DU RONGEUR ARVICOLA TERRESTRIS SCHERMAN - 2024
- DISPOSITIF DE TRAITEMENT PAR PLASMA ATMOSPHERIQUE FROID - 2024