iGReD G¨¦n¨¦tique, Reproduction et D¨¦veloppement
UMR 6293 CNRS / UMR 1103 Inserm / UCA
- Adresse :
- UFR de Pharmacie / UFR de M¨¦decine et des Professions param¨¦dicales
TSA 50400
28, Place Henri Dunant
63001 CLERMONT-PT招财进宝
- T¨¦l :
- 04-73-17-81-70
- Sur Internet :
- www.gred-clermont.fr/
Responsables
- Directeur de laboratoire
- Krzysztof JAGLA
- Directrice Adjointe
- Anne FOGLI
- Gestionnaire d'unit¨¦
- Franck TEILLET franck.teillet@uca.fr
- Gestionnaire d'unit¨¦
- Veronique TRONCY veronique.troncy@uca.fr
Composition ¨¦quipe ( effectif total : 164 )
- BOUVIER Damien -
- CHIAMBARETTA Frederic -
- COSTE Karen -
- FOGLI Anne -
- FUTIER Emmanuel -
- GALLOT Denis -
- GOUMY Carole -
- JABAUDON Matthieu -
- MARCEAU Geoffroy -
- QUINARD Regine -
- SAPIN DEFOUR Vincent -
- TAUVERON Igor -
- BARDOT Olivier -
- BARON Silvere -
- BEAUDOIN Claude -
- BLANCHON Loic -
- BRASSET Emilie -
- CAIRA Francoise -
- CALET Corinne -
- COTTERELL Sylviane -
- DE JOUSSINEAU Cyrille -
- DREVET Joel -
- GUITON Rachel -
- KOCER Ayhan -
- LAGEIX Sebastien -
- LE GOFF Samuel -
- LOBACCARO Jean Marc -
- MARTINEZ Anne Marie -
- MOREL Laurent -
- OSTEIL Pierre -
- POINTUD Jean Christophe -
- SAEZ Fabrice -
- SOLER Cedric -
- TATOUT Christophe -
- TROUSSON Amalia -
- TUTOIS Sylvie -
- VAILLANT Isabelle -
- VANROBAYS Emmanuel -
- VAURS BARRIERE Catherine -
- ROSZYK Laurence -
- AMIARD Simon -
- ARNAUD Philippe -
- CHARBONNEAU Michel -
- CHAZAUD Claire -
- COURT Franck -
- DA INES Olivier -
- DEGOUL Francoise -
- EYCHENNE Julia -
- GRANDIN Nathalie -
- GUILLOT Charlene -
- JAGLA Krzysztof -
- JENSEN Silke -
- JUNION Guillaume -
- MARTINEZ Antoine -
- MATHIEU Olivier -
- MIROUSE Vincent -
- MOLARO Antoine -
- PELISSIER Thierry -
- PROBST Aline -
- SERRA Heidi -
- VAL Pierre -
- VANDEL Laurence -
- VOLLE David -
- WALTZER Lucas -
- WHITE Charles -
- BELVILLE Corinne -
- DESSET Sophie -
- IMBERT ROUX Lauriane -
- JAGLA Teresa -
- MAUPETIT MEHOUAS Stephanie -
- MOUTY Lea -
- PELISSIER Marie Noelle -
- POUCHIN Pierre -
- RENAUD Yoan -
- VACHIAS Caroline -
- ALEGOT Herve -
- ALLEGRE Nicolas -
- BARNOLA Isabelle -
- BOUTOURLINSKY Katia -
- CLERICI Ornella -
- CRUZEL Jonas -
- DAMON Christelle -
- DE HAZE Angelique -
- FRAISSE Marine -
- GARNIER Cecile -
- GERDY Vincent -
- GONTHIER GUERET Celine -
- HOLOTA Helene -
- MORDIER Joris -
- PERILLOUS Sophie -
- REY Celia -
- RICHARD Graziella -
- RONGIER Ga?tan -
- TEILLET Franck -
- VADOT Francoise -
- GARCIA GARCIA Diana -
- KAUR Raminder -
- KUMAR Rohit -
- MATA SUCRE Yennifer -
- MAURELIA GAETE Felipe Alonso -
- MONTIBUS Bertille -
- OLIVIER Margaux -
- PANG Won Ki -
- PRINCE Elodie -
- SANMUKH Swapnil Ganesh -
- TOMASEK Ines -
- VOISIN Allison -
- ANGLARET Nadege -
- BERTRAND Romane -
- BRAVARD Stephanie -
- BRUNEL Maryse -
- BUISINE Monique -
- CADENA Claire -
- DIOMANDE Corinne -
- GOMEZ Eric -
- GUEGUEN Nathalie -
- MARTINEZ Marie Jose -
- PRADEL Vanessa -
- SANCHEZ VILLAVICENCIO Phelipe -
- TRONCY Veronique -
- VERBEKE Jeremy -
- VERDIER Manon -
- BAABDATY Elissa -
- BADOIL Lena -
- BIOLET Eloise -
- BRUGIERE Line -
- CHALEIL Florian -
- DAJOUX Gabin -
- DE SOUSA Martina -
- DELPORTE Norberta -
- EL IDRISSI MOUBTASSIM Hafsa -
- FEIT Lea -
- GERDY Vincent -
- HARISMENDY Nathan -
- JUVEN Aurelien -
- KAHOUADJI Samy -
- KARAM Germaine -
- KUZNETSOVA Ekaterina -
- LASCOVITCH Leila -
- LENOIR Naell -
- LUGOBONI Margot -
- LUZZI Irene -
- MAGALES Chloee -
- MIGNY Chloe -
- MOCHET Etienne -
- OLABE Julie -
- PALTRINIERI Stefania -
- PARACCHINI Sara -
- PATIN Anaelle -
- PAULUS Violaine -
- PETIOT Valentine -
- PRIKSHIT Prikshit -
- PURAVET Antoine -
- PUTTINI PAIXAO Joao -
- ROBIN Justine -
- SIRETA Gilles -
- TESTE Camille -
- THEILLIERE Camille -
- WEST Elliot -
- HENRIOUX Fanny -
- KAHOUADJI Samy -
- OUEDRAOGO Zangbewende Guy -
- RAGOT Elia -
- SIMON Lauriane -
Equipes
- CODED : ChrOmatin & 3D nuclEar Dynamics , Christophe TATOUT , Aline PROBST
- Diversification of muscle and heart cells in normal and pathological conditions , Krzysztof JAGLA
- Dynamic Regulation of Body Axis Morphogenesis , Charlene GUILLOT
- ERO : Epigenetic Regulation & Ontogenesis , Lucas WALTZER
- Environment, Spermatogenesis, Pathophysiology and Inheritance , David VOLLE
- Epithelial growth and Morphogenesis , Vincent MIROUSE
- Evolutionary Epigenomics and Genetic Conflicts , Antoine MOLARO
- Genomic Imprinting and the epigenetic control of cell fate determination , Philippe ARNAUD
- Gin&Co : Genetic instabilities and control by the host genome , Emilie BRASSET , Chantal VAURY
- Molecular Pathophysiology of @drenal & Endocrine Tissues , Antoine MARTINEZ , Pierre VAL
- Molecular mechanisms of cell lineage differentiation in the early mouse embryon , Claire CHAZAUD
- NuReP : Nuclear Receptors and Prostate diseases , Silvere BARON , Jean Marc LOBACCARO
- Recombination and maintenance of genome integrity , Charles WHITE
- SiLENT : Silencing, Environment and Transposons , Olivier MATHIEU
- Transliational approach to epithelial injury and repair , Vincent SAPIN DEFOUR
Th¨¨mes de Recherche
Version Fran?aise English versionLe iGReD (Laboratoire de G¨¦n¨¦tique, Reproduction et D¨¦veloppement) cherche ¨¤ comprendre les m¨¦canismes mol¨¦culaires et cellulaires qui contr?lent la formation d'un organisme eucaryote ¨¤ partir d'un oeuf f¨¦cond¨¦. Les ¨¦quipes qui le composent, analysent les syst¨¨mes de surveillance et de r¨¦paration qui maintiennent l'int¨¦grit¨¦ des g¨¦nomes. Elles ¨¦tudient comment d'une cellule indiff¨¦renci¨¦e, divisions et diff¨¦renciations cellulaires conduisent ¨¤ la formation d'un individu harmonieusement d¨¦velopp¨¦.
Prolongeant ces aspects fondamentaux, des approches m¨¦dicales visent ¨¤ ¨¦lucider le programme g¨¦n¨¦tique d'une cellule saine, identifier les d¨¦r¨¦gulations de certaines pathologies, et trouver des th¨¦rapeutiques adapt¨¦es.
Cette unit¨¦ se d¨¦cline en trois th¨¨mes majeurs:
Dynamique du g¨¦nome et contr?le ¨¦pig¨¦n¨¦tique,
Reproduction et d¨¦veloppement normal et pathologique
Endocrinologie et signalisation,
Les approches utilis¨¦es allient biologie mol¨¦culaire et cellulaire, imagerie et cribles g¨¦n¨¦tiques. L'utilisation de plusieurs mod¨¨les eucaryotes (vert¨¦br¨¦s, insectes, plantes) permet d'exploiter les avantages particuliers de chacun.
Research in the GReD concerns the molecular and cellular mechanisms brought into play to ensure maintenance of genome integrity and gene expression, differentiation and development. Our research concerns three major themes:
Genome dynamics and epigenetic control
reproduction and development in health and disease
Endocrinology and signaling
The three research axes thus combine molecular and cellular biology approaches, imaging and genetic screens. The use of multiple biological models (vertebrates, insects, plants) permits us to exploit the particular advantages of each for research and experimentation. This work, and notably the study of human genetic diseases including cancer, has great potential for technology transfer to clinical applications - in line with our strategic scientific policy to strengthen the continuum between basic and clinical research.
The strengths of the Unit:
Complementarity of technical approaches and models.
Coordination and sharing of cutting-edge technical facilities.
High potential for the transfer of technology to clinical applications, in keeping with the marketing policy.
Significant training activities within universities in Clermont-Ferrand.
Publications ( HAL )
- ¦Â-Catenin activation and illicit receptor expression in adrenocortical cells
Julie Le Mestre , Micha?l Thomas , C¨¦line Duparc , Pierre Val , Cl¨¦mence Bures , Jean-Jacques Tuech , Jean-Christophe Sabourin , St¨¦phanie Baert-Desurmont , Herv¨¦ Lefebvre , Estelle Louiset - Loss of SUMO-specific protease 2 causes isolated glucocorticoid deficiency by blocking adrenal cortex zonal transdifferentiation in mice
Damien Dufour , Typhanie Dumontet , Isabelle Sahut-Barnola , Aude Carusi , M¨¦line Onzon , Eric Pussard , James Jr Wilmouth , Julie Olabe , C¨¦cily Lucas , Adrien Levasseur , Christelle Damon-Soubeyrand , Jean-Christophe Pointud , Florence Roucher-Boulez , Igor Tauveron , Guillaume Bossis , Edward Yeh , David Breault , Pierre Val , Anne-Marie Lefran?ois-Martinez , Antoine Martinez - Visual hallucinations and illusions in Parkinson¡¯s disease: the role of ocular pathology
Ana Marques , Steven Beze , Bruno Pereira , Carine Chassain , Nathalie Monneyron , Laure Delaby , Celine Lambert , Marie Fontaine , Philippe Derost , B¨¦reng¨¨re Debilly , Isabelle Rieu , Simon Lewis , Fr¨¦d¨¦ric Chiambaretta , Franck Durif - Two-year longitudinal follow-up of visual illusions and hallucinations in Parkinson¡¯s disease
Steven Beze , Lucia Castellani , Bruno Pereira , Fr¨¦d¨¦ric Chiambaretta , Franck Durif , Ana Marques - NLRP7 promotes Choriocarcinoma growth and progression through the establishment of an immunosuppressive microenvironment
Deborah Reynaud , Roland Abi Nahed , Nicolas Lemaitre , Pierre-Adrien Bolze , Wael Traboulsi , Frederic Sergent , Christophe Battail , Odile Filhol , Vincent Sapin , Houssine Boufettal , Pascale Hoffmann , Touria Aboussaouira , Padma Murthi , Rima Slim , Mohamed Benharouga , Nadia Alfaidy - The Plant Mobile Domain proteins antagonize the Polycomb group protein- mediated gene silencing
Jarry Lucas , P¨¦lissier Thierry , Olivier Margaux , Dajoux Gabin , Pouch-P¨¦lissier M.N. , Courtois Charles , Descombin Julie , Picault Nathalie , Moissiard Guillaume , Mathieu Olivier - Culture of per-wound bone specimens: a simplified approach for the medical management of diabetic foot osteomyelitis
O. Lesens , F. Desbiez , M. Vidal , Fr¨¦d¨¦ric Robin , S. Descamps , J. Beytout , H. Laurichesse , I. Tauveron - Plant Mobile Domain proteins antagonize the Polycomb group protein-mediated gene silencing
Jarry Lucas , P¨¦lissier Thierry , Olivier Margaux , Dajoux Gabin , Pouch-P¨¦lissier M.N. , Courtois Charles , Descombin Julie , Picault Nathalie , Moissiard Guillaume , Mathieu Olivier - The Plant Mobile Domain proteins antagonize the Polycomb group protein-mediated gene silencing
Jarry Lucas , P¨¦lissier Thierry , Olivier Margaux , Dajoux Gabin , Pouch-P¨¦lissier M.N. , Courtois Charles , Descombin Julie , Picault Nathalie , Moissiard Guillaume , Mathieu Olivier - CFSE flow cytometric quantification of lymphocytic proliferation in extracorporeal photopheresis: Use for quality control
Bertrand Evrard , Annie Dosgilbert , Nathalie Jacquemot , Fran?ois Demeocq , Thibault Gilles , Jacques Chassagne , Marc Berger , Arlette Tridon
Production scientifique depuis 2021
- DIAGNOSTIC DE L'OXYDATION DU NOYAU SPERMATIQUE - 2022
- Utilisation du dosage sanguin de la chimiokine CX3CL1 chez la femme enceinte - 2023
- CARACTERISATION DE PEPTIDES ANTIGENIQUES / IMMUNOGENIQUES POUR LE DEVELOPPEMENT DE VACCINS CONTRACEPTIFS DANS LE BUT DE LIMITER LES PULLULATIONS DU RONGEUR ARVICOLA TERRESTRIS SCHERMAN - 2024
- DISPOSITIF DE TRAITEMENT PAR PLASMA ATMOSPHERIQUE FROID - 2024