iGReD G¨¦n¨¦tique, Reproduction et D¨¦veloppement
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UMR 6293 CNRS / UMR 1103 Inserm / UCA
- Adresse :
- UFR de Pharmacie / UFR de M¨¦decine et des Professions param¨¦dicales
TSA 50400
28, Place Henri Dunant
63001 CLERMONT-PT招财进宝
- T¨¦l :
- 04-73-17-81-70
- Sur Internet :
- www.gred-clermont.fr/
Responsables
- Directeur de laboratoire
- Krzysztof JAGLA
- Directrice Adjointe
- Anne FOGLI
- Gestionnaire d'unit¨¦
- Franck TEILLET franck.teillet@uca.fr
- Gestionnaire d'unit¨¦
- Veronique TRONCY veronique.troncy@uca.fr
Composition ¨¦quipe ( effectif total : 158 )
- BOUVIER Damien -
- CHIAMBARETTA Frederic -
- COSTE Karen -
- FOGLI Anne -
- FUTIER Emmanuel -
- GALLOT Denis -
- JABAUDON Matthieu -
- MARCEAU Geoffroy -
- QUINARD Regine -
- SAPIN DEFOUR Vincent -
- TAUVERON Igor -
- BARDOT Olivier -
- BARON Silvere -
- BEAUDOIN Claude -
- BLANCHON Loic -
- BRASSET Emilie -
- CAIRA Francoise -
- CALET Corinne -
- COTTERELL Sylviane -
- DE JOUSSINEAU Cyrille -
- DREVET Joel -
- GALLEGO Maria Eugenia -
- GUITON Rachel -
- KOCER Ayhan -
- LAGEIX Sebastien -
- LE GOFF Samuel -
- LOBACCARO Jean Marc -
- MARTINEZ Anne Marie -
- MOREL Laurent -
- OSTEIL Pierre -
- POINTUD Jean Christophe -
- SAEZ Fabrice -
- SOLER Cedric -
- TATOUT Christophe -
- TROUSSON Amalia -
- TUTOIS Sylvie -
- VAILLANT Isabelle -
- VANROBAYS Emmanuel -
- VAURS BARRIERE Catherine -
- ROSZYK Laurence -
- AMIARD Simon -
- ARNAUD Philippe -
- CHARBONNEAU Michel -
- CHAZAUD Claire -
- COURT Franck -
- DA INES Olivier -
- DEGOUL Francoise -
- EYCHENNE Julia -
- GRANDIN Nathalie -
- GUILLOT Charlene -
- JAGLA Krzysztof -
- JENSEN Silke -
- JUNION Guillaume -
- MARTINEZ Antoine -
- MATHIEU Olivier -
- MIROUSE Vincent -
- MOLARO Antoine -
- PELISSIER Thierry -
- PROBST Aline -
- SERRA Heidi -
- VAL Pierre -
- VANDEL Laurence -
- VOLLE David -
- WALTZER Lucas -
- WHITE Charles -
- BELVILLE Corinne -
- DESSET Sophie -
- JAGLA Teresa -
- MAUPETIT MEHOUAS Stephanie -
- MOUTY Lea -
- PELISSIER Marie Noelle -
- POUCHIN Pierre -
- RENAUD Yoan -
- RENGIFO ROJAS Cecilia -
- TERZIAN Paul -
- VACHIAS Caroline -
- ALEGOT Herve -
- ALLEGRE Nicolas -
- BARNOLA Isabelle -
- BATTISTELLI Edwige -
- BOUTOURLINSKY Katia -
- CLERICI Ornella -
- CRUZEL Jonas -
- DAMON Christelle -
- DE HAZE Angelique -
- FRAISSE Marine -
- GONTHIER GUERET Celine -
- HOLOTA Helene -
- MORDIER Joris -
- PERILLOUS Sophie -
- POURPE Charlene -
- QUENEC HDU Ronan -
- RICHARD Graziella -
- TEILLET Franck -
- THEILLIERE Camille -
- VADOT Francoise -
- AKKOUCHE Abdou -
- CERQUEIRA CAMPOS Fabiana -
- GARCIA GARCIA Diana -
- KUMAR Rohit -
- MATA SUCRE Yennifer -
- MONTIBUS Bertille -
- OLIVIER Margaux -
- PANG Won Ki -
- PRINCE Elodie -
- SANMUKH Swapnil Ganesh -
- TOMASEK Ines -
- VOISIN Allison -
- ANGLARET Nadege -
- BRAVARD Stephanie -
- BRUNEL Maryse -
- BUISINE Monique -
- CADENA Claire -
- DIOMANDE Corinne -
- GOMEZ Eric -
- GUEGUEN Nathalie -
- MARTINEZ Marie Jose -
- PRADEL Vanessa -
- SANCHEZ VILLAVICENCIO Phelipe -
- VERBEKE Jeremy -
- VERDIER Manon -
- ANTOINE Audrey -
- BAABDATY Elissa -
- BADOIL Lena -
- BIOLET Eloise -
- BRUGIERE Line -
- CHALEIL Florian -
- CHARNAY Coline -
- CHERON Floriane -
- DAJOUX Gabin -
- DE SOUSA Martina -
- DELPORTE Norberta -
- FEIT Lea -
- GERDY Vincent -
- HARISMENDY Nathan -
- HOLOTA Helene -
- KAHOUADJI Samy -
- KARAM Germaine -
- KUZNETSOVA Ekaterina -
- LUGOBONI Margot -
- MALEK Lynda -
- MARTINS Aline -
- MOAZAMIAN Aron -
- MOCHET Etienne -
- OLABE Julie -
- PALTRINIERI Stefania -
- PARACCHINI Sara -
- PATIN Anaelle -
- PETIOT Valentine -
- PRIKSHIT Prikshit -
- PURAVET Antoine -
- QUENEC'HDU Ronan -
- ROBIN Justine -
- SIRETA Gilles -
- TESTE Camille -
- WEST Elliot -
- KAHOUADJI Samy -
- SIMON Lauriane -
Equipes
- CODED : ChrOmatin & 3D nuclEar Dynamics , Christophe TATOUT , Aline PROBST
- Diversification of muscle and heart cells in normal and pathological conditions , Krzysztof JAGLA
- Dynamic Regulation of Body Axis Morphogenesis , Charlene GUILLOT
- ERO : Epigenetic Regulation & Ontogenesis , Lucas WALTZER
- Environment, Spermatogenesis, Pathophysiology and Inheritance , David VOLLE
- Epithelial growth and Morphogenesis , Vincent MIROUSE
- Evolutionary Epigenomics and Genetic Conflicts , Antoine MOLARO
- Genomic Imprinting and the epigenetic control of cell fate determination , Philippe ARNAUD
- Gin&Co : Genetic instabilities and control by the host genome , Emilie BRASSET , Chantal VAURY
- Molecular Pathophysiology of @drenal & Endocrine Tissues , Antoine MARTINEZ , Pierre VAL
- Molecular mechanisms of cell lineage differentiation in the early mouse embryon , Claire CHAZAUD
- NuReP : Nuclear Receptors and Prostate diseases , Silvere BARON , Jean Marc LOBACCARO
- Recombination and maintenance of genome integrity , Charles WHITE
- SiLENT : Silencing, Environment and Transposons , Olivier MATHIEU
- Transliational approach to epithelial injury and repair , Vincent SAPIN DEFOUR
Th¨¨mes de Recherche
Version Fran?aise English versionLe iGReD (Laboratoire de G¨¦n¨¦tique, Reproduction et D¨¦veloppement) cherche ¨¤ comprendre les m¨¦canismes mol¨¦culaires et cellulaires qui contr?lent la formation d'un organisme eucaryote ¨¤ partir d'un oeuf f¨¦cond¨¦. Les ¨¦quipes qui le composent, analysent les syst¨¨mes de surveillance et de r¨¦paration qui maintiennent l'int¨¦grit¨¦ des g¨¦nomes. Elles ¨¦tudient comment d'une cellule indiff¨¦renci¨¦e, divisions et diff¨¦renciations cellulaires conduisent ¨¤ la formation d'un individu harmonieusement d¨¦velopp¨¦.
Prolongeant ces aspects fondamentaux, des approches m¨¦dicales visent ¨¤ ¨¦lucider le programme g¨¦n¨¦tique d'une cellule saine, identifier les d¨¦r¨¦gulations de certaines pathologies, et trouver des th¨¦rapeutiques adapt¨¦es.
Cette unit¨¦ se d¨¦cline en trois th¨¨mes majeurs:
Dynamique du g¨¦nome et contr?le ¨¦pig¨¦n¨¦tique,
Reproduction et d¨¦veloppement normal et pathologique
Endocrinologie et signalisation,
Les approches utilis¨¦es allient biologie mol¨¦culaire et cellulaire, imagerie et cribles g¨¦n¨¦tiques. L'utilisation de plusieurs mod¨¨les eucaryotes (vert¨¦br¨¦s, insectes, plantes) permet d'exploiter les avantages particuliers de chacun.
Research in the GReD concerns the molecular and cellular mechanisms brought into play to ensure maintenance of genome integrity and gene expression, differentiation and development. Our research concerns three major themes:
Genome dynamics and epigenetic control
reproduction and development in health and disease
Endocrinology and signaling
The three research axes thus combine molecular and cellular biology approaches, imaging and genetic screens. The use of multiple biological models (vertebrates, insects, plants) permits us to exploit the particular advantages of each for research and experimentation. This work, and notably the study of human genetic diseases including cancer, has great potential for technology transfer to clinical applications - in line with our strategic scientific policy to strengthen the continuum between basic and clinical research.
The strengths of the Unit:
Complementarity of technical approaches and models.
Coordination and sharing of cutting-edge technical facilities.
High potential for the transfer of technology to clinical applications, in keeping with the marketing policy.
Significant training activities within universities in Clermont-Ferrand.
Publications ( HAL )
- Regionally specific levels and patterns of keratin 8 expression in the mouse embryo visceral endoderm emerge upon anterior-posterior axis determination
Evang¨¦line Despin-Guitard , Ronan Quenec¡¯hdu , Wallis Nahaboo , Nicole Schwarz , Rudolf Leube , Claire Chazaud , Isabelle Migeotte - A comprehensive evolutionary scenario for the origin and neofunctionalization of the Drosophila speciation gene Odysseus (OdsH)
William Vilas Boas Nunes , Daniel Siqueira de Oliveira , Guilherme de Rezende Dias , Antonio Bernardo Carvalho , ?caro Putinhon Caruso , Joice Matos Biselli , Nathalie Guegen , Abdou Akkouche , Nelly Burlet , Cristina Vieira , Claudia Carareto - Casting histone variants during mammalian reproduction
Germaine Karam , Antoine Molaro - Formation aux enqu¨ºtes de terrain. Programmes biogaz dans deux communes rurales du district rural de Ho¨¤ Vang, province de ?¨¤ N?ng
Pierre-Yves Le Meur , Emmanuel Pannier , Olivier Tessier - Exploring adaptive spaces towards sustainable rice in Cambodia
Alexia Dayet , Jean-Christophe Castella , Jean-Christophe Diepart , Sreypich Lim - Bacteriophage T4 polynucleotide kinase triggers degradation of mRNAs
Sylvain Durand , Graziella Richard , Fran?ois Bontems , Marc Uzan - Antioxidant, Anti-inflammatory and Cytotoxic Properties of Cancerol S, A Blend of Medicinal Plants, on Cancerous Cells in Culture
Marc Donald Wilfried Adico , Bagora Bayala , Florencia Wendkuuni Djigma , Bapio Valerie Elvira Jean Telesphore Bazi¨¦ , Paul Darga , Jean-Marc Lobaccaro , Jacques Simpor¨¦ - PIWI Slicing and RNA Elements in Precursors Instruct Directional Primary piRNA Biogenesis.
David Homolka , Radha Raman Pandey , Coline Goriaux , Emilie Brasset , Chantal Vaury , Ravi Sachidanandam , Marie-Odile Fauvarque , S. Pillai - Small-scale managed marine areas over time : developments and challenges in a local Fijian reef fishery
Elodie Fache , A. Breckwoldt - Introduction: An interdisciplinary overview of some climate-related narratives and responses in the Pacific
Elodie Fache , Pascal Dumas , Antoine de Ramon N¡¯yeurt
Production scientifique depuis 2020
- NOYAU-HD - 2020 - Clermont-Fd - Journ¨¦es d 'Etudes - R¨¦gionale
- DIAGNOSTIC DE L'OXYDATION DU NOYAU SPERMATIQUE - 2022
- Utilisation du dosage sanguin de la chimiokine CX3CL1 chez la femme enceinte - 2023