iGReD G¨¦n¨¦tique, Reproduction et D¨¦veloppement

UMR 6293 CNRS / UMR 1103 Inserm / UCA

Adresse :

UFR de Pharmacie / UFR de M¨¦decine et des Professions param¨¦dicales
TSA 50400
28, Place Henri Dunant
63001 CLERMONT-PT招财进宝

T¨¦l :

04-73-17-81-70

Sur Internet :

www.gred-clermont.fr/

Responsables

Directeur de laboratoire

Krzysztof JAGLA

Directrice Adjointe

Anne FOGLI

Responsable administratif

Franck TEILLET franck.teillet@uca.fr

Gestionnaire d'unit¨¦

Veronique TRONCY veronique.troncy@uca.fr

Composition ¨¦quipe ( effectif total : 167 )

Equipes

• CODED : ChrOmatin & 3D nuclEar Dynamics , Christophe TATOUT , Aline PROBST
• Diversification of muscle and heart cells in normal and pathological conditions , Krzysztof JAGLA
• Dynamic Regulation of Body Axis Morphogenesis , Charlene GUILLOT
• ERO : Epigenetic Regulation & Ontogenesis , Lucas WALTZER
• Environment, Spermatogenesis, Pathophysiology and Inheritance , David VOLLE
• Epithelial growth and Morphogenesis , Vincent MIROUSE
• Evolutionary Epigenomics and Genetic Conflicts , Antoine MOLARO
• Genomic Imprinting and the epigenetic control of cell fate determination , Philippe ARNAUD
• Gin&Co : Genetic instabilities and control by the host genome , Emilie BRASSET , Chantal VAURY
• Molecular Pathophysiology of @drenal & Endocrine Tissues , Antoine MARTINEZ , Pierre VAL
• Molecular mechanisms of cell lineage differentiation in the early mouse embryon , Claire CHAZAUD
• NuReP : Nuclear Receptors and Prostate diseases , Silvere BARON , Jean Marc LOBACCARO
• Recombination and maintenance of genome integrity , Charles WHITE
• SiLENT : Silencing, Environment and Transposons , Olivier MATHIEU
• Transliational approach to epithelial injury and repair , Vincent SAPIN DEFOUR

Th¨¨mes de Recherche

Version Fran?aise English version

Le iGReD (Laboratoire de G¨¦n¨¦tique, Reproduction et D¨¦veloppement) cherche ¨¤ comprendre les m¨¦canismes mol¨¦culaires et cellulaires qui contr?lent la formation d'un organisme eucaryote ¨¤ partir d'un oeuf f¨¦cond¨¦. Les ¨¦quipes qui le composent, analysent les syst¨¨mes de surveillance et de r¨¦paration qui maintiennent l'int¨¦grit¨¦ des g¨¦nomes. Elles ¨¦tudient comment d'une cellule indiff¨¦renci¨¦e, divisions et diff¨¦renciations cellulaires conduisent ¨¤ la formation d'un individu harmonieusement d¨¦velopp¨¦.

Prolongeant ces aspects fondamentaux, des approches m¨¦dicales visent ¨¤ ¨¦lucider le programme g¨¦n¨¦tique d'une cellule saine, identifier les d¨¦r¨¦gulations de certaines pathologies, et trouver des th¨¦rapeutiques adapt¨¦es.

Cette unit¨¦ se d¨¦cline en trois th¨¨mes majeurs:

    Dynamique du g¨¦nome et contr?le ¨¦pig¨¦n¨¦tique,

    Reproduction et d¨¦veloppement normal et pathologique

    Endocrinologie et signalisation,

Les approches utilis¨¦es allient biologie mol¨¦culaire et cellulaire, imagerie et cribles g¨¦n¨¦tiques. L'utilisation de plusieurs mod¨¨les eucaryotes (vert¨¦br¨¦s, insectes, plantes) permet d'exploiter les avantages particuliers de chacun.

Research in the GReD concerns the molecular and cellular mechanisms brought into play to ensure maintenance of genome integrity and gene expression, differentiation and development. Our research concerns three major themes:

    Genome dynamics and epigenetic control

    reproduction and development in health and disease

    Endocrinology and signaling

The three research axes thus combine molecular and cellular biology approaches, imaging and genetic screens. The use of multiple biological models (vertebrates, insects, plants) permits us to exploit the particular advantages of each for research and experimentation. This work, and notably the study of human genetic diseases including cancer, has great potential for technology transfer to clinical applications - in line with our strategic scientific policy to strengthen the continuum between basic and clinical research.

The strengths of the Unit:

    Complementarity of technical approaches and models.

    Coordination and sharing of cutting-edge technical facilities.

    High potential for the transfer of technology to clinical applications, in keeping with the marketing policy.

    Significant training activities within universities in Clermont-Ferrand.

Publications ( HAL )

• Personalized driving pressure-guided positive end-expiratory pressure in patients at risk of postoperative respiratory failure (IMPROVE-2): a multicenter, pragmatic, randomized clinical trial.
  Emmanuel Futier , Audrey de Jong , C¨¦dric Cirenei , Thomas Godet , Matthieu Jabaudon , Jean-Michel Constantin , Nicolas Grillot , Pierre Bouzat , L Henry , D Margetis , Gilles Lebuffe , Marc Garnier , C¨¦line Lambert , Bruno Pereira , Samir Jaber
• The impact of redox stress on the genetic/epigenetic integrity of mammalian spermatozoa
  Aron Moazamian
• Microenvironnement immunitaire dans le corticosurr¨¦nalome : ami ou ennemi ?
  Pierre Val
• Sexually dimorphic activation of innate antitumour immunity prevents adrenocortical carcinoma development in male mice, following Znrf3 inactivation
  Pierre Val
• The immune microenvironment of adrenocortical carcinoma.
  Pierre Val
• Impact of the immune microenvironment on sexual dimorphism of ACC and new avenues of treatment. ¡°Why Sex Matters¡±
  Pierre Val
• Testosterone creates a BRCA-like state in adrenocortical carcinomas
  Pierre Val
• Sexual dimorphism in the adenal cortex: from physiology to ACC treatment.
  Pierre Val
• Targeting senescent macrophages inhibits metastatic dissemination in adrenocortical cancer
  Pierre Val
• Potential of testosterone-mediated DNA damage and senescence induction as a novel therapeutic approach in adrenocortical carcinoma
  Pierre Val

Production scientifique depuis 2021

Brevets (4)

• CARACTERISATION DE PEPTIDES ANTIGENIQUES / IMMUNOGENIQUES POUR LE DEVELOPPEMENT DE VACCINS CONTRACEPTIFS DANS LE BUT DE LIMITER LES PULLULATIONS DU RONGEUR ARVICOLA TERRESTRIS SCHERMAN - 2024
• DISPOSITIF DE TRAITEMENT PAR PLASMA ATMOSPHERIQUE FROID - 2024
• DIAGNOSTIC DE L'OXYDATION DU NOYAU SPERMATIQUE - 2022
• Utilisation du dosage sanguin de la chimiokine CX3CL1 chez la femme enceinte - 2023