iGReD G¨¦n¨¦tique, Reproduction et D¨¦veloppement

UMR 6293 CNRS / UMR 1103 Inserm / UCA
- Adresse :
- UFR de Pharmacie / UFR de M¨¦decine et des Professions param¨¦dicales
TSA 50400
28, Place Henri Dunant
63001 CLERMONT-PT招财进宝
- T¨¦l :
- 04-73-17-81-70
- Sur Internet :
- www.gred-clermont.fr/
Responsables
- Directeur de laboratoire
- Krzysztof JAGLA
- Directrice Adjointe
- Anne FOGLI
- Gestionnaire d'unit¨¦
- Franck TEILLET franck.teillet@uca.fr
- Gestionnaire d'unit¨¦
- Veronique TRONCY veronique.troncy@uca.fr
Composition ¨¦quipe ( effectif total : 168 )
- BOUVIER Damien -
- CHIAMBARETTA Frederic -
- COSTE Karen -
- FOGLI Anne -
- FUTIER Emmanuel -
- GALLOT Denis -
- GOUMY Carole -
- JABAUDON GANDET Matthieu -
- MARCEAU Geoffroy -
- QUINARD Regine -
- SAPIN DEFOUR Vincent -
- TAUVERON Igor -
- BARDOT Olivier -
- BARON Silvere -
- BEAUDOIN Claude -
- BLANCHON Loic -
- BRASSET Emilie -
- CAIRA Francoise -
- CALET Corinne -
- COTTERELL Sylviane -
- DE JOUSSINEAU Cyrille -
- DREVET Joel -
- GUITON Rachel -
- KOCER Ayhan -
- LAGEIX Sebastien -
- LE GOFF Samuel -
- LOBACCARO Jean Marc -
- MARTINEZ Anne Marie -
- MOREL Laurent -
- OSTEIL Pierre -
- POINTUD Jean Christophe -
- SAEZ Fabrice -
- SOLER Cedric -
- TATOUT Christophe -
- TROUSSON Amalia -
- TUTOIS Sylvie -
- VAILLANT Isabelle -
- VANROBAYS Emmanuel -
- VAURS BARRIERE Catherine -
- ROSZYK Laurence -
- AMIARD Simon -
- ARNAUD Philippe -
- CHARBONNEAU Michel -
- CHAZAUD Claire -
- COURT Franck -
- DA INES Olivier -
- DEGOUL Francoise -
- EYCHENNE Julia -
- GRANDIN Nathalie -
- GUILLOT Charlene -
- JAGLA Krzysztof -
- JENSEN Silke -
- JUNION Guillaume -
- MARTINEZ Antoine -
- MATHIEU Olivier -
- MIROUSE Vincent -
- MOLARO Antoine -
- PELISSIER Thierry -
- PROBST Aline -
- SERRA Heidi -
- VAL Pierre -
- VANDEL Laurence -
- VOLLE David -
- WALTZER Lucas -
- BARNOLA Isabelle -
- BELVILLE Corinne -
- DESSET Sophie -
- HOLOTA Helene -
- IMBERT ROUX Lauriane -
- JAGLA Teresa -
- MAUPETIT MEHOUAS Stephanie -
- PELISSIER Marie Noelle -
- POUCHIN Pierre -
- RENAUD Yoan -
- TERZIAN Paul -
- VACHIAS Caroline -
- ZMOJDZIAN Monika -
- ALEGOT Herve -
- ALLEGRE Nicolas -
- BEVIA Angelique -
- BOUTOURLINSKY Katia -
- CLERICI Ornella -
- CROUZILLAC Chloe -
- CRUZEL Jonas -
- DAMON Christelle -
- DE HAZE Angelique -
- FRAISSE Marine -
- GARNIER Cecile -
- GERDY Vincent -
- GONTHIER GUERET Celine -
- MORDIER Joris -
- MOUTY Lea -
- PERILLOUS Sophie -
- REY Celia -
- RICHARD Graziella -
- RONGIER Ga?tan -
- TEILLET Franck -
- VADOT Francoise -
- VERDIER Manon -
- AKKOUCHE Abdou -
- CERQUEIRA CAMPOS Fabiana -
- GARCIA GARCIA Diana -
- KAUR Raminder -
- KUMAR Rohit -
- MATA SUCRE Yennifer -
- MAURELIA GAETE Felipe Alonso -
- MONTIBUS Bertille -
- OLIVIER Margaux -
- PANG Won Ki -
- PRINCE Elodie -
- SANMUKH Swapnil Ganesh -
- VOISIN Allison -
- ANGLARET Nadege -
- BERTRAND Romane -
- BRAVARD Stephanie -
- BRUNEL Maryse -
- BUISINE Monique -
- CADENA Claire -
- DIOMANDE Corinne -
- GOMEZ Eric -
- GUEGUEN Nathalie -
- MARTINEZ Marie Jose -
- PRADEL Vanessa -
- SANCHEZ VILLAVICENCIO Phelipe -
- TRONCY Veronique -
- VERBEKE Jeremy -
- BAABDATY Elissa -
- BADOIL Lena -
- BIOLET Eloise -
- BRUGIERE Line -
- CHALEIL Florian -
- DAJOUX Gabin -
- DE SOUSA Martina -
- DELPORTE Norberta -
- EL IDRISSI MOUBTASSIM Hafsa -
- FEIT Lea -
- GERDY Vincent -
- HARISMENDY Nathan -
- JUVEN Aurelien -
- KAHOUADJI Samy -
- KARAM Germaine -
- KUZNETSOVA Ekaterina -
- LASCOVITCH Leila -
- LENOIR Naell -
- LUGOBONI Margot -
- MAGALES Chloee -
- MIGNY Chloe -
- MOCHET Etienne -
- OLABE Julie -
- PALTRINIERI Stefania -
- PARACCHINI Sara -
- PATIN Anaelle -
- PAULUS Violaine -
- PETIOT Valentine -
- PRIKSHIT Prikshit -
- PURAVET Antoine -
- PUTTINI PAIXAO Joao -
- RENARD TRICHE Laurent -
- ROBIN Justine -
- SIRETA Gilles -
- TESTE Camille -
- THEILLIERE Camille -
- WEST Elliot -
- HENRIOUX Fanny -
- KAHOUADJI Samy -
- OUEDRAOGO Zangbewende Guy -
- RAGOT Elia -
- SIMON Lauriane -
Equipes
- CODED : ChrOmatin & 3D nuclEar Dynamics , Christophe TATOUT , Aline PROBST
- Diversification of muscle and heart cells in normal and pathological conditions , Krzysztof JAGLA
- Dynamic Regulation of Body Axis Morphogenesis , Charlene GUILLOT
- ERO : Epigenetic Regulation & Ontogenesis , Lucas WALTZER
- Environment, Spermatogenesis, Pathophysiology and Inheritance , David VOLLE
- Epithelial growth and Morphogenesis , Vincent MIROUSE
- Evolutionary Epigenomics and Genetic Conflicts , Antoine MOLARO
- Genomic Imprinting and the epigenetic control of cell fate determination , Philippe ARNAUD
- Gin&Co : Genetic instabilities and control by the host genome , Emilie BRASSET , Chantal VAURY
- Molecular Pathophysiology of @drenal & Endocrine Tissues , Antoine MARTINEZ , Pierre VAL
- Molecular mechanisms of cell lineage differentiation in the early mouse embryon , Claire CHAZAUD
- NuReP : Nuclear Receptors and Prostate diseases , Silvere BARON , Jean Marc LOBACCARO
- Recombination and maintenance of genome integrity , Charles WHITE
- SiLENT : Silencing, Environment and Transposons , Olivier MATHIEU
- Transliational approach to epithelial injury and repair , Vincent SAPIN DEFOUR
Th¨¨mes de Recherche
Version Fran?aise English versionLe iGReD (Laboratoire de G¨¦n¨¦tique, Reproduction et D¨¦veloppement) cherche ¨¤ comprendre les m¨¦canismes mol¨¦culaires et cellulaires qui contr?lent la formation d'un organisme eucaryote ¨¤ partir d'un oeuf f¨¦cond¨¦. Les ¨¦quipes qui le composent, analysent les syst¨¨mes de surveillance et de r¨¦paration qui maintiennent l'int¨¦grit¨¦ des g¨¦nomes. Elles ¨¦tudient comment d'une cellule indiff¨¦renci¨¦e, divisions et diff¨¦renciations cellulaires conduisent ¨¤ la formation d'un individu harmonieusement d¨¦velopp¨¦.
Prolongeant ces aspects fondamentaux, des approches m¨¦dicales visent ¨¤ ¨¦lucider le programme g¨¦n¨¦tique d'une cellule saine, identifier les d¨¦r¨¦gulations de certaines pathologies, et trouver des th¨¦rapeutiques adapt¨¦es.
Cette unit¨¦ se d¨¦cline en trois th¨¨mes majeurs:
Dynamique du g¨¦nome et contr?le ¨¦pig¨¦n¨¦tique,
Reproduction et d¨¦veloppement normal et pathologique
Endocrinologie et signalisation,
Les approches utilis¨¦es allient biologie mol¨¦culaire et cellulaire, imagerie et cribles g¨¦n¨¦tiques. L'utilisation de plusieurs mod¨¨les eucaryotes (vert¨¦br¨¦s, insectes, plantes) permet d'exploiter les avantages particuliers de chacun.
Research in the GReD concerns the molecular and cellular mechanisms brought into play to ensure maintenance of genome integrity and gene expression, differentiation and development. Our research concerns three major themes:
Genome dynamics and epigenetic control
reproduction and development in health and disease
Endocrinology and signaling
The three research axes thus combine molecular and cellular biology approaches, imaging and genetic screens. The use of multiple biological models (vertebrates, insects, plants) permits us to exploit the particular advantages of each for research and experimentation. This work, and notably the study of human genetic diseases including cancer, has great potential for technology transfer to clinical applications - in line with our strategic scientific policy to strengthen the continuum between basic and clinical research.
The strengths of the Unit:
Complementarity of technical approaches and models.
Coordination and sharing of cutting-edge technical facilities.
High potential for the transfer of technology to clinical applications, in keeping with the marketing policy.
Significant training activities within universities in Clermont-Ferrand.
Publications ( HAL )
- National expert consensus on the management of antibiotic prophylaxis in surgical patients with a penicillin allergy label based on the Delphi method
Aur¨¦lie Gouel-Ch¨¦ron , Catherine Neukirch , Annick Barbaud , Axelle Dupont , Jean-Ralph Zahar , Solen Kern¨¦is , Marc Garnier , Gabriel Birgand , Sara Romano-Bertrand , Philippe Lesprit , Sylvain Diamantis , Remy Gauzit , Estelle Marcault , Marc Leone , Matthieu Boisson , Claire Roger , Claire Dahyot-Fizelier , Pascal Demoly , Anca Chiriac , Philippe Montravers - Keratoconus and the Impact of Treatment on Patients¡¯ Quality of Life: A Qualitative Study
Pierre Fourni¨¦ , Micha?l Acquadro , David Touboul , B¨¦atrice Cochener , Fr¨¦d¨¦ric Chiambaretta , Marc Muraine , Vincent Borderie , Jean-Louis Bourges , Khadra Benmedjahed , B¨¦atrice Tugaut , Diane Bernheim , Tristan Bourcier , Carole Burillon , Thierry David , Bernard Delbosc , Philippe Gain , Louis Hoffart , Marc Labetoulle , Laurent Laroche , Florence Malet - Keratoconus and the Impact of Treatment on Patients¡¯ Quality of Life: A Qualitative Study
Pierre Fourni¨¦ , Micha?l Acquadro , David Touboul , B¨¦atrice Cochener , Fr¨¦d¨¦ric Chiambaretta , Marc Muraine , Vincent Borderie , Jean-Louis Bourges , Khadra Benmedjahed , B¨¦atrice Tugaut , Diane Bernheim , Tristan Bourcier , Carole Burillon , Thierry David , Bernard Delbosc , Philippe Gain , Louis Hoffart , Marc Labetoulle , Laurent Laroche , Florence Malet - Breastfeeding after Returning to Work: A Systematic Review and Meta-Analysis
Fr¨¦d¨¦ric Dutheil , Gr¨¦gory M¨¦chin , Philippe Vorilhon , Amanda C. Benson , Anne Bottet , Ma?lys Clinchamps , Chlo¨¦ Barasinski , Valentin Navel - Consensus on the Management of Anesthetic Agents During Digestive Motility Measurements and Proposal of a Standardized Protocol for Anesthesia (French Neuro Gastroenterology Group GFNG and Committee of Anesthetic French Experts)
Domitille Renard , Thomas Clavier , Osama Abou-Arab , G¨¦rard Amarenco , Emmanuel Besnier , Alice Blet , Matthieu Boisson , Charl¨¨ne Brochard , Benoit Coffin , Audrey de Jong , Denis Frasca , Marc Garnier , Aurelie Gouel , J¨¦r¨¦mie Jacques , Arthur James , Yoann Launey , Anne©\marie Leroi , Chlo¨¦ Melchior , Daphn¨¦ Michelet , Fran?ois Mion - The mutational landscape of ARMC5 in Primary Bilateral Macronodular Adrenal Hyperplasia: an update
Lucas Bouys , Anna Vaczlavik , Isadora P Cavalcante , Florian Violon , Anne Jouinot , Annabel Berthon , Patricia Vaduva , St¨¦phanie Espiard , Karine Perlemoine , Peter Kamenicky , Marie-Christine Vantyghem , Antoine Tabarin , G¨¦rald Raverot , Cristina L Ronchi , Ulrich Dischinger , Martin Reincke , Maria C Fragoso , Constantine A Stratakis , Albain Chansavang , Eric Pasmant - Innovative Trajectory Analysis Reveals Dynamics and Risk Factors of Post©\Kidney Transplant Diabetes Mellitus in a French Cohort
Julie Olabe , Cyril Garrouste , Bruno Pereira , Charlotte Colosio , Antoine Thierry , Jean©\philippe Rerolle , Dominique Bertrand , Ma?t¨¦ Jaureguy , L¨¦onard Goblin , Mathias Buchler , Yannick Le Meur , Valerie Chatelet , Jean©\fran?ois Augusto , Igor Tauveron , Marie Batisse-Lignier , Anne Elizabeth Heng - WORKSHOP - Data storage and curation - Biology and Health Community (OMERO)
Sophie Desset , Nadia Gou¨¦ , Francis Ogereau - Prevalence of FGF23 elevation in patients with hypophosphatemia
Charlotte Oris , Alexandre Lautrette , Aurore Doug¨¦ , Farouk Bouraima , Samy Kahouadji , Marie-Eva Pickering , Cyril Garrouste , Johan Gagni¨¨re , Romain Gui¨¨ze , Nicolas d'Ostrevy , Emmanuel Futier , Vincent Grobost , Anthony Buisson , Marie Batisse , Jean-Baptiste Bouillon-Minois , Bruno Pereira , Julie Durif , Vincent Sapin , Damien Bouvier - The stn1-sz2 Mutant Provides New Insight into the Impacts of Telomeric Cdc13-Stn1-Ten1 Dysfunction on Cell Cycle Progression
Michel Charbonneau , Nathalie Grandin
Production scientifique depuis 2021
- DIAGNOSTIC DE L'OXYDATION DU NOYAU SPERMATIQUE - 2022
- Utilisation du dosage sanguin de la chimiokine CX3CL1 chez la femme enceinte - 2023
- CARACTERISATION DE PEPTIDES ANTIGENIQUES / IMMUNOGENIQUES POUR LE DEVELOPPEMENT DE VACCINS CONTRACEPTIFS DANS LE BUT DE LIMITER LES PULLULATIONS DU RONGEUR ARVICOLA TERRESTRIS SCHERMAN - 2024
- DISPOSITIF DE TRAITEMENT PAR PLASMA ATMOSPHERIQUE FROID - 2024