Microbes Intestin Inflammation et Susceptibilit¨¦ de l¡¯H?te
UMR 1071 Inserm / UCA
- Adresse :
- UFR de Pharmacie / UFR de M¨¦decine et des Professions param¨¦dicales
TSA 50400
28, Place Henri Dunant
63001 CLERMONT-PT招财进宝
- T¨¦l :
- +33 4 73 17 79 97
- Sur Internet :
- m2ish.uca.fr
Responsables
- Gestionnaire d'unit¨¦
- Magalie BLANCHETON magalie.blancheton@uca.fr
Composition ¨¦quipe ( effectif total : 54 )
- ANDRE Marc -
- AUMAITRE Olivier -
- BONNET Richard -
- BUISSON Anthony -
- DELMAS Julien -
- GAGNIERE Johan -
- GODFRAIND Catherine -
- NOURRISSON Celine -
- PEZET Denis -
- POIRIER Philippe -
- ROBIN Frederic -
- BILLARD Elisabeth -
- BONNET Mathilde -
- BOUCHER Delphine -
- DALMASSO Guillaume -
- DENIZOT Jeremy -
- LIVRELLI Valerie -
- NGUYEN Hang -
- NIU Dongyan -
- BEYROUTHY Racha -
- FAURE Frederic -
- HOANG Thi My Hanh -
- SAUVANET Pierre -
- BEYROUTI Malak -
- CHEVARIN Caroline -
- CROUZILLAC Chloe -
- LECLAIRE Charlotte -
- RODRIGUES Michael -
- BECHON DIOT Celine -
- BLANCHETON Magalie -
- BODIER Nathan -
- BONNIN Virginie -
- FABRE Gwenaelle -
- GUILLOUARD Laurent -
- MARTIN Lucas -
- MICHAUX Arnaud -
- REZARD Alexandra -
- BOTCHORICHVILI Helene -
- COLOMBIE Sibylle -
- CROS Eugenie -
- DAMBRINE Flavie -
- DE CLERCQ Fanny -
- DESSEUX Coline -
- DEVAUX Amandine -
- FARGEAS Margot -
- JOUBERT Morgane -
- JUBAN Charline -
- ONZON Meline -
- VERCRUYSSE Leslie -
- BIRER Aurelien -
- GAU Laurence -
- JOUBERT Morgane -
- MARTIN JARY Marine -
- MAURIN Eugenie -
Th¨¨mes de Recherche
Version Fran?aise English version Un dialogue permanent s¡¯¨¦tablit dans le tube digestif entre le micobiote et l¡¯h?te et tout d¨¦s¨¦quilibre de cette symbiose est ¨¤ l¡¯origine de nombreuses pathologies. L¡¯UMR 1071 Inserm/universit¨¦ d¡¯Auvergne m¨¨ne depuis une dizaine d¡¯ann¨¦es des travaux consistant ¨¤ analyser la relation bact¨¦ries-h?te en ¨¦tudiant les Escherichia coli pathog¨¨nes impliqu¨¦s dans les maladies inflammatoires chroniques du tube digestif, en particulier la maladie de Crohn (MC) et les E. coli ent¨¦roh¨¦morragiques responsables de diarrh¨¦es aigu?s et de syndrome h¨¦molytique et ur¨¦mique. Nous avons plus particuli¨¨rement ¨¦t¨¦ pionniers dans la mise en ¨¦vidence que la muqueuse il¨¦ale des patients atteints de MC ¨¦tait anormalement colonis¨¦e par Escherichia coli. Notre hypoth¨¨se est que le d¨¦veloppement de la MC pourrait ¨ºtre li¨¦ ¨¤ une susceptibilit¨¦ g¨¦n¨¦tique des patients ¨¤ ¨ºtre colonis¨¦s par les souches pathog¨¨nes de Escherichia coli (adherent-invasive E. coli ou AIEC) qui sont capables d¡¯adh¨¦rer et de promouvoir leur internalisation dans les cellules ¨¦pith¨¦liales intestinales, de survivre et de se multiplier dans les cellules macrophagiques. De plus, en raison du lien fort qui existe entre inflammation chronique et cancer, nous avons ¨¦galement ouvert un nouveau sujet d¡¯¨¦tude concernant la piste infectieuse ¨¤ E. coli dans le d¨¦veloppement de cancer colorectal.
Nous d¨¦veloppons principalement trois axes de recherche : (i) exploration de la virulence de Escherichia coli responsables de pathologies inflammatoires intestinales, (ii) ¨¦tude de la pr¨¦disposition de l¡¯h?te ¨¤ l¡¯infection par E. coli dans la maladie de Crohn et le cancer colorectal, et (iii) d¨¦veloppement de nouvelles th¨¦rapies sp¨¦cifiques.
There is an ongoing dialogue in the digestive tract between microbiota and the host. Any imbalance in this symbiosis leads to many diseases, such as chronic inflammatory bowel diseases, colorectal cancer, obesity, metabolic syndrome. For the last ten years, the research unit ¡°Microbes, Intestine, Inflammation and Host Susceptibility¡±, UMR 1071 Inserm/Universit¨¦ d¡¯Auvergne, INRA USC 2018, has been studying the relationship between intestinal microbiota and the host, particularly the involvement of pathogenic Escherichia coli in chronic inflammatory bowel diseases, focusing on Crohn's disease and the role of enterohemmoragic E. coli involved in acute diarrhea and hemolytic uremic syndrome. This research unit is pioneer in demonstrating that the ileal mucosa of patients with Crohn's disease was abnormally colonized by pathogenic adherent-invasive Escherichia coli due to genetic susceptibility of Crohn¡¯s disease patients with increased expression of intestinal receptor allowing E. coli colonization and/or with defects in autophagy, a cellular process allowing host cells to eliminate any intracellular pathogens. In addition, due to the strong link between chronic inflammation and cancer, this research unit also studies the link between modifications of the intestinal microbiota and colorectal cancer.
This unit is currently developing three areas of research: (i) exploration of the virulence of Escherichia coli responsible for chronic inflammatory bowel diseases and colorectal cancer, (ii) analysis of the host susceptibility to develop Crohn's disease or colorectal cancer, and (iii) design of new specific therapies.
Publications ( HAL )
- Search for gravitational-lensing signatures in the full third observing run of the LIGO-Virgo network
R Abbott , H Abe , F Acernese , K Ackley , S Adhicary , N Adhikari , R.X Adhikari , V.K Adkins , V.B Adya , C Affeldt , D Agarwal , M Agathos , O.D Aguiar , L Aiello , A Ain , P Ajith , T Akutsu , S Albanesi , R.A Alfaidi , C All¨¦n¨¦ - Antihyperalgesic properties of gut microbiota: Parabacteroides distasonis as a new probiotic strategy to alleviate chronic abdominal pain
Sandie Gervason , Mathieu Meleine , St¨¦phane Lolignier , Ma?va Meynier , Valentine Daugey , Aur¨¦lien Birer , Youssef Aissouni , Jean-Yves Berthon , Denis Ardid , Edith Filaire , Fr¨¦d¨¦ric Antonio Carvalho - Pasteurized <i>Akkermansia muciniphila</i> improves irritable bowel syndrome-like symptoms and related behavioral disorders in mice
Ma?va Meynier , Valentine Daugey , Geoffroy Mallaret , Sandie Gervason , Mathieu Meleine , Julie Barbier , Youssef Aissouni , St¨¦phane Lolignier , Mathilde Bonnet , Denis Ardid , Willem M de Vos , Matthias van Hul , Peter Suenaert , Amandine Brochot , Patrice D Cani , Fr¨¦d¨¦ric A Carvalho - Observation of Gravitational Waves from the Coalescence of a $2.5-4.5~M_\odot$ Compact Object and a Neutron Star
A.G Abac , R Abbott , I Abouelfettouh , F Acernese , K Ackley , S Adhicary , N Adhikari , R.X Adhikari , V.K Adkins , D Agarwal , M Agathos , M. Aghaei Abchouyeh , O.D Aguiar , I Aguilar , L Aiello , A Ain , P Ajith , S Ak?ay , T Akutsu , S Albanesi - Les productions audiovisuelles : des annexes aux chapitres ?
Egidio Marsico , Christian Dury - A Versatile Cyclic Clickable Platform by Ring-Expansion Metathesis Polymerization: Cyclic Glycopolymers with Lectin-Binding Ability
Cl¨¦ment Gonnot , Mathieu Scalabrini , Benoit Roubinet , Zo¨¦ Oblette , Adeline Sivignon , Fabien Boeda , David Deniaud , Ludovic Landemarre , Nicolas Barnich , S¨¦bastien Gouin , Laurent Fontaine , V¨¦ronique Montembault - Phosphorylation of Extracellular Proteins in Acinetobacter baumannii in Sessile Mode of Growth
S¨¦bastien Massier , Brandon Robin , Marianne M¨¦groz , Amy Wright , Marina Harper , Brooke Hayes , Pascal Cosette , Isabelle Broutin , John Boyce , Emmanuelle D¨¦ , Julie Hardouin - Interactions between intestinal microbiota, mucus layer and dietary fiber: towards preventive strategies to mitigate virulence of food-borne pathogen Enterotoxigenic Escherichia coli.
Thomas Sauvaitre , Josefien van Landuyt , Claude Durif , Charl¨¨ne Roussel , Adeline Sivignon , Oph¨¦lie Uriot , Florence van Herreweghen , Tom van de Wiele , St¨¦phanie Blanquet-Diot , Lucie Etienne-Mesmin - Targeting the endo-lysosomal autophagy pathway to treat inflammatory bowel diseases
Sruthi Vijaya Retnakumar , Ramasatyaveni Geesala , Alexis Bretin , Julien Tourneur-Marsille , Eric Ogier-Denis , Thorsten Maretzky , Hang Thi Thu Nguyen , Sylviane Muller - Impact of HIV Infection on the Course of Inflammatory Bowel Disease and Drug Safety Profile: A Multicenter GETAID Study
Lucas Guillo , Mathieu Uzzan , Laurent Beaugerie , Jean-Marc Gornet , Aur¨¦lien Amiot , Anne-Laure Pelletier , Romain Altwegg , David Laharie , Vered Abitbol , J¨¦r?me Filippi , Felix Goutorbe , Maria Nachury , St¨¦phane Nancey , St¨¦phanie Viennot , Catherine Reenaers , Morgane Amil , Ludovic Caillo , Anthony Buisson , Michael Collins , Laurence Picon
Production scientifique depuis 2020
- Inhibiteurs glycosidiques de levures - 2021
Reconnaissance de l'excellence
- ERA-NET - 2008 COLIEVOL
- Bourses CURIE - 2011 MIRNA-AIEC
- ERA-NET - Pathogenomics
- ANR 2012 - STARLET
- ANR 2013 - Nutribiote
- ANR 2013 - COMeBACk